Dehydrogenation of 3-Aminoflavanone

Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes.

3-Methylindole (3 MI) is a selective pulmonary toxicant, and cytochrome P450 (P450) bioactivation of 3 MI, through hydroxylation, epoxidation, or dehydrogenation pathways, is a prerequisite for toxicity. CYP2F1 and CYP2F3 exclusively catalyze the dehydrogenation of 3 MI to 3-methyleneindolenine, without detectable formation of the hydroxylation or epoxidation products. It was not known whether ...

Dehydrogenation of Benzene on Liquid

The reactions of benzene on Al100 + have been investigated as a function of cluster temperature (300−1100 K) and relative kinetic energy (1−14 eV) by low-energy ion-beam methods and mass spectrometry. Benzene chemisorbs on both solid and liquid aluminum clusters to generate Al100C6D6 . A series of Al100−n + (n = 1, 2, 3, ...) products was also observed. As the cluster temperature was raised abo...

Dehydrogenation by Heterogeneous Catalysts

Dehydration, dehydrogenation, and condensation of alcohols on supported oxide catalysts based on cyclic (WO3)3 and (MoO3)3 clusters.

Supported early transition metal oxides have important applications in numerous catalytic reactions. In this article, we review the synthesis and activity of well-defined model WO3 and MoO3 catalysts that are prepared via deposition of cyclic gas-phase (WO3)3 and (MoO3)3 clusters generated by sublimation of WO3 and MoO3 powders. Conversion of small aliphatic alcohols to alkenes, aldehydes/keton...

Short Communication SELECTIVE DEHYDROGENATION/OXYGENATION OF 3-METHYLINDOLE BY CYTOCHROME P450 ENZYMES

3-Methylindole (3 MI) is a selective pulmonary toxicant, and cytochrome P450 (P450) bioactivation of 3 MI, through hydroxylation, epoxidation, or dehydrogenation pathways, is a prerequisite for toxicity. CYP2F1 and CYP2F3 exclusively catalyze the dehydrogenation of 3 MI to 3-methyleneindolenine, without detectable formation of the hydroxylation or epoxidation products. It was not known whether ...